There was no clear research evidence to support the effect of hydrogen on hypertension in the past. The school of pharmacy of the Second Military Medical University once found that injecting hydrogen physiological saline into spontaneously hypertensive animals could not reduce blood pressure, but could reduce the damage of blood vessels and organs caused by hypertension. This seems to be a comfort to people, that is, although hydrogen can not reduce blood pressure, it is also important to reduce the damage of target organs.
However, the experimental results of failing to reduce hypertension are also embarrassing, because we have always emphasized that hydrogen has anti-oxidation and anti-inflammatory effects, and inflammation and oxidative damage are also key factors involved in the formation of hypertension, and can play a role in dyslipidemia and arteriosclerosis. How to treat high blood pressure, which is also a metabolic disease and also a chronic inflammatory disease, cannot be effective. These studies also lead us not to recommend clinical trials of hypertension. However, the incidence rate of hypertension is almost one of the highest among all chronic diseases.
If hydrogen has no effect on hypertension, it is a pity for this star molecule with broad-spectrum biological effects. However, the information provided from many cases shows that the blood pressure of hypertensive patients who have been drinking hydrogen water and inhaling hydrogen for a long time will gradually decrease. Some hypertensive patients may even have hypotension due to taking drugs at the same time. Of course, there are also some cases where the blood pressure does not decrease but increases in the early stage of hydrogen use. The research related to hypertension is that hydrogen can reduce the proportion of patients with uremia who use hypertension drugs
In December 2020, 1、the Scientific Report published a report from the medical school of Keio University in Japan, which studied the hypertension caused by the removal of most of the kidneys, mainly in the hope of studying renal hypertension. The animals inhaled only 1.3% hydrogen for 1 hour every day for 4 weeks, which could significantly reduce blood pressure. Even if the animals were treated with hydrogen inhalation 3 weeks after nephrectomy, it still showed certain effect. The study further studied the basis of hydrogen treatment on hypertension, and found that hydrogen inhalation can inhibit the hyperactive sympathetic nervous system and enhance the activity of the parasympathetic nervous system, so as to restore the balance of the unbalanced autonomic nerve.
The study authors believe that inflammation related injury may affect the autonomic nerve function through the brain, leading to increased sympathetic excitability and decreased parasympathetic activity, and the comprehensive result may lead to increased blood pressure. Hydrogen treatment can suppress the inflammatory reaction in the brain and promote the recovery of autonomic nerve balance. So as to reduce hypertension
This study provides an important basis for the clinical research of hydrogen treatment of hypertension in the future. Since the incidence rate of hypertension is very high, and the diagnosis of hypertension is relatively objective, non-invasive technology can also be used for analysis. In particular, it is very beneficial to analyze the effect of hydrogen by combining wearable devices to collect relevant data such as heart rate. Considering the position of autonomic nerve in blood pressure control, human studies can also combine this detection
The inhaled hydrogen used in the study was 1.3%, which is a very low hydrogen dose, approximately equivalent to 100-200 ml of hydrogen intake per minute. In the human body test, it is safe and simple to inhale about 300 ml of pure hydrogen as the hydrogen supply method. I hope to see the results of this clinical trial come out soon
The results showed that hydrogen had a decrease in systolic blood pressure and mean arterial pressure, but had no effect on diastolic blood pressure
Abstract: a recent clinical study showed that hemodialysis with hydrogen containing dialysate can improve blood pressure control in patients with end-stage renal disease. Here, we investigated whether hydrogen has beneficial effects on hypertension in animal models. We made rats with 5 / 6 kidneys removed to inhale hydrogen (1.3% hydrogen + 21% oxygen + 77.7% nitrogen) or a control group (21% oxygen + 79% nitrogen) gas mixture every day for 1 hour. After 5 / 6 nephrectomy, hydrogen inhalation can significantly inhibit the rise of blood pressure. The antihypertensive effect of hydrogen was also confirmed in rats with stable hypertension 3 weeks after nephrectomy. To examine the detailed effects of hydrogen on hypertension, an implantable telemetry system was used to continuously monitor blood pressure.
The results showed that hydrogen not only had hypotensive effect during daytime rest, but also had hypotensive effect during nighttime activities. The analysis of blood pressure change spectrum shows that hydrogen can improve autonomic imbalance by inhibiting the hyperactive sympathetic nervous system and enhancing the activity of the parasympathetic nervous system. These effects occur simultaneously with the hypotensive effect. In conclusion, in an animal model of hypertension, exposure to hydrogen for 1 hour per day has an antihypertensive effect
Main references
Sugai, K., Tamura, T., Sano, M. et al. Daily inhalation of hydrogen gas has a blood pressure-lowering effect in a rat model of hypertension. Sci Rep 10, 20173 (2020).
Wang Y, Jing L, Zhao XM, Han JJ, Xia ZL, Qin SC, Wu YP, Sun XJ. Protective effects of hydrogen-rich saline on monocrotaline-induced pulmonary hypertension in a rat model. Respir Res. 2011 Mar 4; 12(1):26. doi: 10.1186/1465-9921-12-26. PMID: 21375753; PMCID: PMC3065415.
Yang X, Guo L, Sun X, Chen X, Tong X. Protective effects of hydrogen-rich saline in preeclampsia rat model. Placenta. 2011 Sep; 32(9):681-686. doi: 10.1016/j.placenta.2011.06.020. Epub 2011 Jul 20. PMID: 21764125.
Zheng H, Yu YS. Chronic hydrogen-rich saline treatment attenuates vascular dysfunction in spontaneous hypertensive rats. Biochem Pharmacol. 2012 May 1; 83(9):1269-77. doi: 10.1016/j.bcp.2012.01.031. Epub 2012 Feb 9. PMID: 22342731.
Yu YS, Zheng H. Chronic hydrogen-rich saline treatment reduces oxidative stress and attenuates left ventricular hypertrophy in spontaneous hypertensive rats. Mol Cell Biochem. 2012 Jun; 365(1-2):233-42. doi: 10.1007/s11010-012-1264-4. Epub 2012 Feb 18. PMID: 22350760.
